The benzofuran nucleus and derivatives occupy a position of considerable significance for widespread occurrence in\r\nplants and their potential as important pharmaceuticals. It has also been reported that benzofuran derivative possess\r\nbacteriostatic, bactericidal, fungistatic, fungicidal activities. The natural products possessing benzofuran nucleus are frequently\r\nassociated with useful pharmacological properties. This fact created interest in synthetic products containing benzofuran\r\nnucleus. Kreamer and Spilker discovered benzofuran in coal tar. It was synthesized by Perkin in 1870. Thus the chemistry of\r\nbenzofuran has developed in a spectacular fashion during the last several years. Natural benzofuran compounds have varied\r\nchemical structures. They exist in simple form such as a substituted benzofuran to highly complicated molecule like morphine.\r\nDue to wide scope for synthetic investigations leading to more potent synthetic leads, voluminous synthetic work has been\r\nproduced so far.
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